Sohana speaking at #WEDay UK on 9 March 2016
Lenticol -M Mesenchymal Stromal Cells engineered to express Collagen VII for the treatment of RDEB
Dr Waseem Qasim, Professor J McGrath, Francesco Dazzi
Further info A trial is currently underway to test the ability of fibroblasts to provide collagen VII in the skin of patients with RDEB. The trial will provide important information on the safety and feasibility of localised injections of engineered cells into the skin. We now want to prepare for a more generalised approach using bone marrow derived cells called MSCs. This project aims to develop reagents and to test gene engineering of MSCs. It will include production of lentiviral vector and testing in an animal model, using human skin grafts from EB patients.
Deep Sequencing Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma
Dr Andrew South (Thomas Jefferson University) and Dr Raymond Cho (Department of Dermatology, University of California)
Patients with recessive dystrophic epidermolysis bullosa (RDEB) frequently develop aggressive, life-threatening cutaneous squamous cell carcinoma (cSCC). Although mechanisms have been proposed to explain why patients suffer this fatal complication, testing such hypotheses requires knowledge of which mutations contribute to the development of RDEB cSCCs. Identifying the mutational landscape of RDEB cSCCs should provide critical insight on how a cancer can develop so quickly in the absence of lifelong sun exposure and DNA damage. Understanding such mechanisms should elucidate modes of prevention and early detection unique to these patients. An increasing number of chemotherapies targeting specific gene mutations are currently in clinical use or development, thus sequencing these cancers may match a known treatment to RDEB patients. This project proposes to sequence 30 RDEB cSCC tumors and matched germ line DNA. This project aims to find tractable therapy options or targets for future development, both clinically and experimentally.
Sohana Research Fund is proud to be a beneficiary of ICAP’s 20th Charity Day. ICAP Charity Day 2012 was held on Wednesday 5th December and raised £11 million worldwide, supporting 200 charities. This brings the total amount raised through ICAP Charity day, which started in 1993, to more than £100 million.
On Tuesday, 5th February, our celebrity supporter Damian Lewis joined representatives from Sohana Research Fund at an event at 10 Downing Street for the 20th ICAP Charity Day Cheque Reception hosted by Samantha Cameron. Also attending the event was ICAP CEO Michael Spencer, other charities and supporters, along with the ICAP Charity Day team. It was a wonderful occasion to mark 20 years of ICAP Charity Day.